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Mitra Akbari

Abstract

We describe a case of long-standing and steroid-dependent adenoviral sub-epithelial corneal infiltrations (SEIs), and its management pattern with topical eye drops interferon alpha-2b (IFN-∝ 2b), and tacrolimus. There is no compressive study about the role of IFN-∝ 2b in the management of adenoviral corneal SEIs. The present study is a case report and review of literatures. A woman aged 31 years suffering from ocular surface burning, decreased vision, and photophobia in her both eyes with a history of two years after acute adenoviral keratoconjunctivitis was referred to our cornea clinic. According to corneal lesions, the adenoviral SEIs had diagnosed. She was dependent on topical steroid therapy, therefore topical tacrolimus 0.05% improved her signs and symptoms, but the tacrolimus eye drop was not available for that time and we have to replace it with 1,000,000 IU/ML eye drop, topical IFN-∝ 2b, and eventually the good visual acuity achieved. In steroid-dependent and refractory adenoviral SEIs, topical tacrolimus and IFN-∝ 2b can equally enhance remission and achieve an excellent visual acuity‎.

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