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The relationship between the hematologic indices after thrombolysis in patients with myocardial infarction

Venus Shahabi Raberi, Reza Faramrza Zadeh, Ebrahim Ezati


The objective of the present study was to determine the relationship between the hematologic indices including MPV and WBC count at the admission time of patients with ST resolution index in patients with STEMI who were treated by thrombolytic agents. In this prospective study, venous blood samples of 114 patients with STEMI were taken to determine PDW, MPV and WBC count at patients' referral time and before thrombolytic therapy. According to ST resolution index in 90 minutes after thrombolytic therapy, patients were classified in two groups with ST resolution less than 50% and ST resolution of 50% or more. In assessing through ROC curve analysis, it was determined that measuring MPV is not considered as an accurate and effective index in predicting ST resolution after thrombolysis (Area Under Curve: 0.574). WBC count was not an applicable indicator for predicting ST resolution after thrombolysis, as well (Area Under Curve: 0.660). Finally, the results of multiple logistic regression model showed that the only predictor of ST resolution less than 50% is the history of using statins so that history of using statin increased the probability of ST resolution less than 50% for 7 times (P: 0.028, OR: 7.306). There is not a relationship between the occurrence of complete ST resolution (more than 50%) and the values of both MPV and WBC indices. So, measuring these two indicators may not have the enough validity for predicting ST resolution after thrombolysis.

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