Abstract

Introduction: diabetes is a prevalent disabling disease which is alarmingly increasing due to individuals’ lifestyle; its level is 5% in Iran. This disease is diagnosed by FBS test. Objectives: the objective of this study was to investigate the FBS fluctuations with serum levels of IL-12 and IL-4 in patients with diabetes. Method: this study was conducted on the case and control groups. The case group included 45 patients with diabetes whose FBS level was higher than 125. 45 healthy people were also selected. The blood sample of all of them was taken and FBS test, IL-12, and IL-4 was done using nephelometry and ELISA method and in accordance with the manufacturer’s kit instruction. Results: the average FBS level in the group with diabetes was approximately 175; it was 95 in the control group. Moreover, in the case group, it was higher than the normal level in 55.5% of the people with IL-4 and 58.7% of the people with IL-12. Conclusion: according to the data, the average serum levels of IL-4 and IL-12 in the people with diabetes whose FBS level was more than 125, was more than the healthy people. The statistical analysis of t-test was done and it was indicated that there is a statistically significant relationship between IL-12 level and FBS fluctuations in people with diabetes. However, there was not a statistically significant relationship between the increased FBS level and IL-4 level in people with diabetes.