Ebrahim Hazrati, Mahtab Noorifard, Mohamad Afsahi, Alireza Rohi, Mohamadreza Rafiei

Abstract

Since severe sepsis result to mass casualties during its course, understanding the factors involved in sepsis prognosis can decrease its morbidities and mortalities. So we conduct this study to evaluate lipid profile and CRP of plasma and patient prognosis. Methods: This observational cohort study was carried out on 60 patient suffering from severe sepsis and hospitalized to Imam Reza ICU ward. Serum lipid profile and CRP were measured on first, third and seventh days and compared with a patient, s SAPS. Data were analyzed on the basis of student’s t – test and χ2 test ANOVA test and within subject ANOVA with repeated measures tests and using SPSS- 18 software. Results: The results are expressed as mean ± SE and P < 0.05 is considered statistically significant. According to our findings CRP level was high on the first, third and seven days in dead patients (p=0.042 p=0.018, p=0.024 respectively). Also triglycerides, LDL and HDL were low on the seventh day (p=0.019, p=0.026, p=0.006 respectively) and had not different on the first and third days(p˃0.05). Conclusion: Severe sepsis prognosis has the relationship with serum lipid profile and CRP. As with a high CRP level and low triglyceride and cholesterol level, the patient will have a poor prognosis.