Abstract

Introduction & Objective: Periodontitis is one of the most common microbial infections in adults known as an inflammatory bacterial disease that affects the protective tissue of the tooth. Ciprofloxacin is a broad-spectrum antibacterial agent that can be used as a systemic drug in the treatment of periodontitis. The aim of this study was to determine the effect of systemic administration of ciprofloxacin antibiotic, along with scaling and root planning (SRP), in the treatment of chronic periodontitis patients. Methods: In this double-blind clinical trial study, 80 patients with chronic periodontitis with inclusion criteria into the study were equally divided into two groups of case and control. At first, the consent form was completed by the patient and the GBI, PD and CAL indices in these patients were measured and recorded in the relevant information form. All patients underwent scaling and root planning (SRP), and health education was given to all patients in a similar way. Patients were asked to avoid using any antimicrobial mouthwash during the study period. Immediately after completing the SRP, patients were randomly assigned to two equal groups of test and control using block randomization. For the case group, ciprofloxacin 500 mg was given twice daily for 7 days and placebo capsule was administered with the same dose and timing sequence for control group. The patient and the prescriber were not aware of the type of drug used. In the first months (before intervention), two and four (after intervention) clinical indexes were recorded. The results were analyzed using SPSS 20 software. Results: In each group, 55% were female and 45% were male. The mean age in the ciprofloxacin group was 47.44 and in the control group was 47.3 years. Before treatment, there was bleeding in the teeth in all of the patients in the two groups. In the second and fourth months, the frequency of patients with bleeding in the ciprofloxacin treatment group was significantly lower than the control group. The GBI, PD, and CAL values in both case and control groups have a significant reduction in clinical parameters over a period of one to three months. Also, the improvement in parameters of GBI, PD and CAL over time in the case group was significantly better than the control group. On the other hand, PD and CAL levels did not significantly differ between men and women at any time. Conclusion: The use of ciprofloxacin with scaling and root planning (SRP) is effective in treating patients with chronic periodontitis.