Abstract

Introduction: Gastric cancer is the uncontrolled growth of malignant cells in the stomach which is one of the most common causes of cancer mortalities worldwide. The prevalence of this cancer is owing to the process of formation of cancerous texture in the stomach in several stages. It is classified as a multifactorial disease, as it forms due to the presence of infectious, environmental and genetic factors in individuals. The main genetic factors are mutations and polymorphisms. Materials and Methods: Information on SNP rs6543115 of IL1RL1 gene was analyzed in 300 subjects (150 patients and 150 healthy individuals). the samples were subjected to sequencing by Sanger method after DNA extraction and PCR to find the effect of this single-nucleotide polymorphism (SNP), and the statistical analysis of genotypes and alleles of individuals was performed by using SPSS. Results: The findings of this study indicated a significant relationship between CC genotype of SNP rs6543115 in IL1RL1 gene and gastric cancer (p <0.03, OR: 2.41, 95% CI: 1.03-5.61) at the molecular level. The percentages of CC, GC and GG genotypes in the patient group were 18, 40 and 42%, respectively, and the corresponding values in the control group were 8, 40 and 52%, respectively. Conclusion: the findings of this study indicated that there is a statistically significant relationship between the CC homozygous genotype of SNP rs6543115 of IL1RL1 gene and the pathogenesis of gastric cancer in the study population.