Abstract

Introduction and necessity: The role of sports activities to reduce the risk factors associated with heart disease, including obesity, high blood pressure, hyperglycemia and hyperinsulinism, are well known, but there is still little information about the potential mechanisms of high intensity periodic interval exercises (HIIT) And aerobic continuity (CT), in the development of adaptations that prevent and even treat cardiovascular disease. Objective: The aim of this study was to investigate the effect of 8 weeks of continuous and periodic aerobic exercises on the expression of BCL-2 and BAX genes in the left ventricle (left ventricular) heart tissue of male Wistar rats. Method and tools: 12 male Wistar rats from the Razi Institute were purchased and all natural conditions (temperature, sleep cycle and awakening, food, etc.) were provided to them. The rats were randomly divided into two groups, the continuous aerobic group (N = 6) and the control group (N = 6). The aerobic continuous aerobic group performed 5 days a week with an intensity of 70% of maximum speed and scheduled time. The following groups were described after each anesthesia, to measure the expression of BCL-2 and BAX genes from the Real Time technique PCR was used. Analysis: SPSS 16 software and the KRUSKAL-WALIS test were used with the MANN-WHITHNEY post hoc test (P <0.05). Results showed that BCL-2 gene expression increased significantly after exercise compared to control group. BAX gene expression decreased in training group compared to control group. Results: Since these two factors are one of the most important factors involved in the process of apoptosis, today research indicates that apoptosis is one of the causes of diseases and cardiac arrest. The results show the positive and influential role of continuous aerobic exercise in preventing cardiovascular disease and treatment of heart failure is.