The activity of curcumin combined with ZnCl2 on streptozotocin-induced diabetic rats: An anti-diabetic, anti-hyperlipidemic study
Diabetes plays a direct role in the development of oxidative stress. Numerous molecules have been evaluated to see whether they can improve diabetes. Curcumin (CUR) and Zinc Chloride (ZnCl2) have various health-beneficial properties. The present study aims to assess the efficacy of CUR combined with ZnCl2 on oxidative changes in Streptozotocin(STZ)-induced diabetes in rats. Forty-eight Albino rats were treated with STZ (60 mg/kg b.w. intraperitoneally) and divided into six groups (G1-G6). G1 was the negative control, while G2 was the positive control. G3,G4 received STZ+CUR (100, 200 mg/kg b.w, respectively). G5 and G6 received (15 mg/kg b.w STZ+ZnCl2 +100 mg/kg b.w CUR) and (15 mg/kg b.w STZ+ZnCl2 +200 mg/kg b.w CUR), respectively. Serum levels of glucose, insulin, lipid profile, liver transaminases (ALT, AST), and lipid peroxidation (GSH, SOD, TBA, and CAT) were determined. Furthermore, morphological changes of the liver were studied. Results: The results showed that glucose, TC, TG, LDL-C, ALT, AST, SOD, TBA, and CAT levels increased, while insulin, HDL-C, and GSH decreased in the STZ group. Treatment with (200 CUR +15 mg/kg b.w ZnCl2) ameliorated these changes with superior results than other groups. The study confirmed that CUR+ZnCl2 improved the oxidative stress condition in rats' serum and tissues; therefore, they could work effectively as preventive agents against STZ- induced diabetes.
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