Seyed Bahman Qader1, Fatemeh Kianizadeh2*, Homeira Rashidi3, Alireza Jahanshahi1, Seyed Peyman Payami1

Abstract

Background: Increased function of the adrenal cortex creates three main groups of clinical syndromes related to elevated hormone levels: Cushing’s syndrome, hyperaldosteronism, and a number of androgenic syndromes. Adrenal mass included: benign and malignant cortical tumor, medullary tumor and others benign lesion. The prevalence of adrenal mass is very different. Therefore, the aim of this study was to determine the prevalence of adrenal masses and assess the clinical, radiological and biochemical characteristics of patients with adrenal masses referring to the Outpatient Clinic to appropriate treatment was designed. Materials and methods: This is a cross-sectional retrospective study in which out of the 100,000 cases in outpatient clinics, 50 patients with adrenal masses that was recruited between 2008 and 2018 was  isolated. Patients' information was collected and analyzed using a checklist including age, sex, pathology of the adrenal mass, adrenal mass size, biochemical of the hormones, blood pressure, and the symptom referring to them and the size of the adrenal mass. Data analysis was performed using SPSS V.22 software. The level of significance was also considered as p <0.05. Results: Of the 50 patients, 32 was female (64%) and 18 (36%) was male. The mean age was 55.66 years for adrenal carcinoma patients and 40.25 years for benign adenoma. 8% was malignant lesions and 92% was benign lesions. . The most common symptom in patients was hypertension (40%) and then asymptomatic patient (24%). non-functional masses was most frequent (54%), followed by benign adenoma (18%). The ferquency of the right adrenal mass (54%) was higher than the left side (40%). 72% of the patients had an adrenal mass less than 4 cm, and all patients with adrenal carcinoma had a mass size greater than 4 cm. in benign adenoma, frequency of smaller than 4 cm in  mass size was higher(77.77%). Conclusion: Given the increased frequency of adrenal masses during these 10 years, suspected patient should undergo hormonal and radiological studies. With early diagnosis and treatment, it is possible to prevent the progression of these lesions and reduce the mortality and morbidity.