Abstract

Introduction: following oral administration, spironolactone may cause stomach inflammation and ulcer. One of the new and promising methods to avoid gastrointestinal irritations, minimize systemic toxicity, and achieve optimal therapeutic effects is administration of this drug through the skin. Studies have shown that SLNs can be used in the treatment of skin diseases such as atopic dermatitis, psoriasis, acne, skin fungus (dermatophytosis) and inflammation. Methodology: Spironolactone-loaded SLNs were prepared as carriers by solvent evaporation method and using palmitic acid. Different weight ratios of carrier to drug and different ratios of Tween and Span were tested with the effect of HLB examined on nanoparticle properties. Optimum formulation was selected to examine the properties of nanoparticles by DSC (Differential scanning calorimetry) and FT-IR (Fourier Transform Infrared) spectroscopy according to the studies conducted. Discussion and conclusion: The results showed that the increase in the lipid and decrease in the drug in formulations F₉ - F₁₅ significantly reduced the average particle size. Thus, in F₁₁, the particle size reduced to 150.8 ± 7.6. Moreover, the highest zeta potential was seen in F₄=-31.73 ± 4.92 and F₁₁=28.36 ± 2.36 with HLB 10.5. By decreasing HLB to 4.3 in F₁₅, zeta potential reduced to -9.6 ± 0.45. The maximum loading rate (4.17 ± 81.3) was observed in F₁₃ formulation with HLB 16.7 and reduced by distancing from this HLB. In this study, the value of the drug released in the dissolution medium increased compared to the standard drug sample.