Shaily Chaudhary, Akash Yadav, Nikunjana Patel, Indrajeet Singhvi

Abstract

Obsessive-Compulsive Disorder (OCD) is a debilitating disease which is characterized by persistent thoughts (obsessions), which are associated with seemingly purposeful ritualistic behavior (compulsions). The effect of acute and chronic administration of agomelatine on the marble-burying behavior (MBB) of mice, which is reported to be an index of anticompulsive behavior, was performed. Results indicated a potent and dose dependent influence of agomelatine on MBB of mice, which was maintained after its chronic administration. However, the higher doses (40 and 50 mg/kg) were found to be locomotor depressant. Treatment with PCPA was not able to inhibit the effect of agomelatine on marble-burying behavior. In conclusion, agomelatine administration reduces the MBB in mice, which should be explored for its potential use in the treatment of OCD.