Hayder Alhamdany , Mohanad Alfahad

Abstract

Assay of acetylsalicylic acid(ASA) utilizing some brands of Aspirin tablets available in Iraqi pharmacies by using direct acid-base titration method and spectrophotometric method for the aim of evaluation of the stability of the active ingredient in their actual environment. Direct acid-base titration method was once used to discover the concentration of active components in aspirin samples then evaluate the result with the percentage of labeling as a reference value. Although the Spectrophotometry approach showed extra correct result than direct acid-base titration when it was once in contrast to the reference value of percentage of labeling due to the excessive fee of accuracy and precision of this method, however direct acid-base titration approach shows no significant difference than the data of spectrophotometer (p-value > 0.05). Both data obtained from spectrophotometry technique and direct acid-base titration assay provide a simple, rapid, cheap, and applicable method for assay of acetylsalicylic acid concentration with a high stage of accuracy‎.

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