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Serum Hepatocytes growth factor in acute and chronic Kidney diseasepatients and its relation to disease activity

Ghada Khalifa Zayet


Background: Chronic kidney disease (CKD) is a major health problem, it is characterized by progressive destruction of functional nephrons, which finally cause end stage kidney disease. Also acute kidney disease (AKD) is a serious condition characterized by acute loss of kidney function with variable degree up to renal failure. One of the important factors in the regulation of cell growth is the hepatocyte growth factor (HGF) which is well known as a mesenchyme-derived pleiotropic, in addition, HGF is playing a role in the morphogenesis of different kinds of cells and cell motility. HGF is a potent renotropic protein that promotes tubular repair and renal regeneration after injurious stimuli. Aim: The aim of the work was to study the correlation between serum HGF level and renal functions of patients with AKD and CKD, including hemodialysis patients. Materials: The study included 62 patients that divided into five groups (of different stages of chronic CKD ((I – V) and AKD in compare to patients with normal renal functions (not including patients with; renal transplantation, malignancies, liver diseases, Pregnancy and lung diseases). All patients were subjected to through case history, clinical examination, chest X ray, abdominal U/S, examination, (BUN, serum creatinine, liver function tests), estimation of GFR by MDRD equation, and serum level of HGF. Results: There was significant increase of serum HGF level in AKI and CKD patients of stages I, II, III and IV, and prompt in patients of stage V specifically patients on regular hemodialysis. Also there was significant correlation between renal sonographic appearance and the serum HGF level as well as the degree of nephropathy and age.

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