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Serum concentrations of CD4+ and CD8+ in patients infected with scabies caused by Sarcoptes scabiei


Ali A. Mohy , Ahmed Abduljabbar Jaloob Aljanaby , Saleem Khteer Al-Hadraawy

Abstract

Background: Scabies is one of the most important epidemic diseases in developing countries infecting males and females especially in rural areas. Therefore, this study aimed to evaluate the cellular immune response in patients infected with scabies caused by Sarcoptes scabiei depended on the measurement serum concentration of T-helper cell (CD4+) and T-cytotoxic cell (CD8+). Materials and Methods: Sixty patients (30 male and 30 female) infected with chronic scabies were included in this study and 30 healthy individuals were considered as control group. CD4+ and CD8+ levels in serum of patients and healthy individuals were measurements by using ELISA device. Results: The results proved that there was a significant increase (P < 0.05) in serum concentrations of CD4+ and CD8+ as compared with control group. On the other hand, the results demonstrated that there was a positive correlation between CD4+ and CD8+ (R2 = 0.0301). Serum concentration of CD8+ was higher than CD4+ with significant increase (P value=0.0001). Conclusion: Human infected with S. scabiei lead to induce higher amounts of Th and Tc cells due to the high levels of production of CD8+ and CD4+ in the serum of patients.




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