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SCL11A1 Gene Polymorphism and susceptibility to Cutaneous Leishmaniasis in Al-Najaf province-Iraq


Luma H. Ali , Saleem Khuteer Al-Hadraawy

Abstract

In many regions of Iraq, cutaneous leishmaniasis (CL) is endemic and the number of patients has been increased during the last 10 years. SLC1A11 gene (Solute Carrier family A 11 member 1 protein), formerly called NRAMP1 (Natural Resistance-Associated Macrophage Protein 1 gene) has an essential role in susceptibility to CL and the disease pathology. This study was aimed to investigate the polymorphisms of SLC1A11 gene and detect a relationship between gene variants and susceptibility to CL infection in Iraqi population/AL-Najaf province. The blood samples were collected from (60) patients with CL and (30) apparently healthy controls. Polymorphism of SLC1A11 575-18G/A was detected in control and patients groups by PCR-RFLP technique. The results were as follows: There was not any significant frequency (p=0.67) in the genetic variations of patients and controls; the frequency of allele G in controls was more than the patients, and the genetic variations of 575-18 G/A are not associated with susceptibility to CL infection.




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