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Reparative-regenerative features of bone tissue in experimental animals treated with titanium implants


Anna Alexandrovna Remizova, Pavel Alanovich Bitarov, Alexander Alibekovich Epkhiev, Nikolay Olegovich Remizov

Abstract

Many researchers are involved in the study of the importance of the material for the manufacture of implants and the influence of these materials on the reparative processes in bone tissue. Metal alloys indicate their high level of influence on the oral mucosa. It is safe to say that studying the effect of implants on body tissues in the future will minimize the number of complications and strengthen the processes of bone remodeling. In this article, we conducted an experiment on Wistar rats with the installation of implants and studied the reparative and regenerative features of bone tissue when using Grade 4 pure titanium implants, as well as Ti6Al7Nb and Ti6Al4V titanium alloys. During the experiment, we determined the best material for the manufacture of dental implants. So, we found that the use of Ti6Al7Nb alloy showed rejection in 87.5% (28 rejections) up to 30 days. The use of Ti6Al4V showed on day 20 rejection of 46.87%% (15 rejected) implants on day 25 (3 individuals) 9.37%% and 43.76% of implants took root in the rat oral cavity. The use of Grade 4 implants showed a pronounced process of bone remodeling in rats, relative to other samples used. All implants were covered with mucosa without any inflammatory processes. Up to 30 days, rejection occurred in 6% of individuals, and 94% of implants took root.


How to cite this article:
Vancouver
Remizova AA, Bitarov PA, Epkhiev AA, Remizov NO. Reparative-regenerative features of bone tissue in experimental animals treated with titanium implants. J Adv Pharm Educ Res. 2022;12(2):110-6. https://doi.org/10.51847/Sprxb1DKyv
APA
Remizova, A. A., Bitarov, P. A., Epkhiev, A. A., & Remizov, N. O. (2022). Reparative-regenerative features of bone tissue in experimental animals treated with titanium implants. Journal of Advanced Pharmacy Education and Research, 12(2), 110-116. https://doi.org/10.51847/Sprxb1DKyv
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