Abstract

Background: Multiple Sclerosis (MS) is a demyelinating autoimmune inflammatory disorder of central neural system associated with neural disability in child bearing age. Studies show that common medicines in the treatment of MS have side effects especially on the reproduction system. Objectives: This study was conducted to examine the protective effects of Aloe Vera alcoholic extract gel on changes of ovarian hormones in experimental model of MS. Methods: In this experimental study, 30 female Wistar rat were randomly assigned to 6 groups (5 in each group). In 20 rat (4 groups) injections of 14 microliter of Anidiom Bromide in the lateral ventricles of brain were made. The 5 other rats were injected with 14 microliter of saline in the lateral ventricle of the brain, and the remaining 5 rats were considered control group. Then 3 groups of MS-induced rats were treated with the alcoholic extract of Aloe Vera gel in dosage of 50 mg/kg, 100 mg/kg, and 200 mg/kg. Finally, all the rats were anesthetized deeply, and then for measuring the serum density of LH, FSH, estrogen and progesterone hormones, blood was taken from their heart. Result: A meaningful increase in the density of LH and FSH hormones, and a meaningful decrease in the density of estrogen and progesterone in group 3 was observed compared with the control group. Also, the density of the progesterone hormone in group 6 compared with group 3 showed a meaningful increase. Conclusion: This study demonstrates that with induction of MS, there will be a decreases in the density of estrogen and progesterone hormones and an increase in the density of gonadotropin hormones; and treatment with extract of Aloe Vera gel has an improving effect on serum levels of sex hormones.