Abstract

Background and aim: serum levels of procalcitonin and of CRP in pregnant woman have been used as laboratory factors in the process of diagnosing placental sepsis. However, different and sometimes contradictory results have been obtained during the studies. In the case of preterm rupture of membranes, the study aims to compare the serum levels of procalcitonin and of CRP as a primary marker of chorioamnionitis in pregnant women. Methods: This investigation was a case - control study. Pregnant women with preterm rupture of membranes and PPROM in 2018, who referred to Ali Ibn Abitaleb Hospital, form a statistical population. The sample size was 110 people who were divided into two groups with equal proportions consisting of two samples (at baseline and with chorioamnionitis) and control group (which included women with healthy membranes). The data we used were collected through two methods such as interviews with patients as well as laboratory data. After importing the data into the computer, SPSS software and independent T-test and correlation were used to analyze. Results: In this study, the results from 110 people studied in relation to the diagnosis of chorioamnionitis showed that in the mother's serum procalcitonin test, the parameters such as sensitivity, specificity, positive predictive value and negative predictive value were 68.2%, 73.9%, 71.4% and 50%, respectively and in the procalcitonin test of the mother's serum before chorioamnionitis (at baseline), the sensitivity, specificity, positive predictive value and negative predictive value were 45.45%, 34.7%, 40% and 41.2%, respectively. Also, in the test for serum procalcitonin in pregnant women with normal membranes, the sensitivity, specificity, positive predictive value and negative predictive value were 36.4%, 43.4%, 38.9% and 41.6%, respectively. Also, according to results of Pearson correlation test in preterm rupture of membranes, a positive and significant relationship between maternal serum levels of procalcitonin and of maternal CRP was observed at baseline and before the end of pregnancy because of chorioamnionitis (P <0.01). Conclusion: The results showed that in prediction of preterm rupture of membranes, the serum procalcitonin and CRP levels in the mother's blood, the chorioamnionitis was effective and in chorioamnionitis during preterm rupture of membranes, there is a positive and significant relationship between serum procalcitonin and CRP. In mothers present in the case group at baseline compared to mothers with normal membranes, high serum levels of procalcitonin and CRP are considered as inflammatory marker.