Prevalence of Hyperthyroidism and Hypothyroidism and its Correlation with Serum Antithyroglobulin among patients in Kirkuk-Iraq
A thyroid hormone biosynthesis disorder within the thyroid gland may lead to hyper or hypothyroidism. This study aimed to estimate the prevalence of thyroid problems in Kirkuk city and to find the correlation between anti-thyroglobulin (Anti-Tg) antibody and thyroid hormone levels. In this study, 88 patients with the age range of 20-50 years (20 males (44.75±14.51 years) and 68 females (39.91±13.66 years)) participated in the study. All biochemical analyses were measured according to immunofluorescent and ELISA assays. There was a significant decrease (P< 0.05) in T3 concentration in male patients as compared to females. In addition, there was a non-significant decrease (P <0.05) in TSH and T4 concentrations in male patients as compared to females. Hyperthyroidism was higher among the age group of (40-49 years), while hypothyroidism was higher among the age group of (30-39 years). At the same time, there was a non-significant decrease (P< 0.05) in the concentration of Ab in male patients as compared to female patients. Significant differences were observed between hyper and hypothyroid patients in the anti-thyroglobulin antibody distributed according to TSH levels. The elevation of the anti-Tg among patients with high T4 was higher (23.07%) than that of normal cases and those with low T4 levels. No significant differences (p< 0.293) were observed among patients with elevated anti-Tg and high T3 levels. It was concluded that there is a clear correlation between the anti-thyroglobulin level and the level of thyroid hormones.
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