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Phytochemical Compositions and in-vitro Anti-inflammatory Activity of Plectranthus mollis

Ushir Yogesh V. , Morankar Pravin G. , Dhake Avinash S


The objective of study was to isolate phytochemicals from Plectranthus mollis and evaluate for anti-inflammatory activity. First time for Plectranthus mollis the study are carried out here for the mentioned activity. The constituents are PMC-1 and PMC-2 were isolated from Plectranthus mollis. The identification of isolated compounds was carried out by various physical, chemical and instrumental techniques. The PMC-1 is identified as - sitosterol and PMC-2 is identified as stigmasterol in Plectranthus mollis . In-vitro anti-inflammatory models were studied; as inhibition of protein denaturation, effect of membrane stabilization of human RBC. We conclude that, the chloroform fraction of Plectranthus mollis shows strong anti-inflammatory activity at different concentration. The chloroform fraction showed dose dependent activity, when compare to aspirin and, hydrocortisone as a standard.

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