Oral nanobilosomes of ropinirole: preparation, compatibility and Ex-vivo intestinal absorption study
Bilosomes are vesicular systems composed of bile salts and non-ionic surfactants with cholesterol. Bilosomal vesicles have numerous benefits compared to liposomes and niosomes. The study aimed to evaluate the compatibility of ropinirole with excipients in bilosomal formulation and compare the intestinal permeation of ropinirole when administered orally in the form of a bilosomal dispersion versus an oral solution. Ropinirole bilosomal dispersion was prepared, optimized, and lyophilized using a freeze dryer to Ropinirole-loading bilosomal powder (Rop-bp) by using mannitol as cryoprotectants. The characteristics of the bilosomal formulations (Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction, field emission scanning electron microscope, and Ex-vivo intestinal permeation study), were evaluated. Fourier Transform Infrared Spectroscopy analysis provided evidence that there was no chemical interaction observed between Ropinirole and the other excipients present in the formulation. Differential scanning calorimetry and X-ray powder diffraction revealed the encapsulation of the amorphous form of ropinirole into bilosomal vesicles, and a scanning electron microscope indicated the spherical shape of bilosomes within the nanometer range (≈155-170nm). The ex-vivo study on intestinal permeation demonstrated that the bilosomes exhibited a notable improvement in intestinal permeation, approximately three times higher than that of the drug solution. In conclusion, results demonstrated no chemical interaction between ropinirole with other excipients in bilosomal formulation. The bilosomes are good carriers for enhancing intestinal permeation of ropinirole.
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