Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol)
In situ gel can be defined as a polymer solution administered as a liquid and when exposed to some physiologic condition such as the pH, ionic, temperature modulation or solvent and UV induced gelation undergo to phase transition to a semisolid gel. Ketotifen fumarate belongs to the histamine H1 receptor antagonists, and Ketotifen fumarate is used in the treatment of allergic conditions like conjunctivitis and rhinitis. This work aims to study the natural polymer effects (xanthan gum,gellan gum) on the properties of pH-trigger in situ ocular gel, then compared the drug-releasing rate of optimized formula with the market ketotifen eye drop. Eight formulations (F1-F8) were prepared using different concentrations of xanthan gum, gellan gum with carpbapol based gel. The best formulation F5 prepared by using0.75% carbapol940 as a gelling agent with 0.3% xanthan gum as a viscosity builder and 0.02% methyl hydroxyl benzoate as a preservative with drug content 99.74%±1.31, pH value, 5.2±0.31, Gel strength 46.6±0.1sec with sustained drug release over period 8h.
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