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Hassan Ali Alhmoud , Yazan HussienAkkam , Derar Al Omari

Abstract

The study aims to investigate the influence of naproxen sodium, excipients, and the dissolution medium on the swelling of tablets. Naproxen sodium was the model drug used in the study. tablets were formulated from different types and ratios of polymers methylcellulose, sodium carboxymethylcellulose (hydrophilic polymers), and cellulose acetate phthalate (hydrophobic polymer) with another excipient. The dimensional changes and shapes were investigated in different dissolution mediums. The results showed that the diameter of naproxen sodium tablets with methylcellulose as an excipient in water reduced, while in the basic media with the buffer of pH 7.4, an increase in the diameter of tablets was observed. In the acidic buffer of pH 1.2, the diameter increased in the first hour from 1.1 cm at zero time to 1.25cm in the second hour and remains in the same diameter until the eighth hour. The results showed that in naproxen tablets with sodium carboxymethylcellulose in water the diameter of the tablets increased, while the higher increase in the tablet diameter was observed in the buffer of pH 7.4. Finally, in the buffer of pH 1.2, no change in the diameter of the tablet was observed during the time of the test. Naproxen tablets with cellulose acetate phthalate in water, diffusion of particles were observed around the tablets like beams, and the diameter of the tablets reduced by time‎.

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