Gite Shital Shridhar, Shinkar Dattatraya Manohar, Saudagar Ravindra Bhanudas

Abstract

The main aim of buccal drug delivery of the drug as potential therapeutic agent is there instability in acidic environment, extensive first pass metabolism and low bioavailability of drug results an inadequate oral absorption. The buccal mucosa is rich in blood supply and relatively permeable. Buccal cavity was found to be most accessible site for both local and systemic delivery of drug. This review highlights that the oral mucosal drug delivery by discussing briefly the structural feature of mucosa, mechanism and theories of bioadhesion. It also contains mucoadhesive polymer, evaluation methods and some of the review on reported research work done on different types of drug by using different mucoadhesive polymers.