Abstract

Of major problems of diabetes, one can refer to DCM, which is associated with increased glucose, apoptosis, decreased IGF-1R gene expression. The beneficial effects of High Intensity Interval Training (HIIT) on the expression of these two genes and the level of glucose and diabetic cardiomyopathy were already confirmed in the past. Hence, the present study investigated the way two types of HIIT are implemented to determine the most optimal type of training. For this, 24 male Wistar rats with an average weight of 320±10 g were selected and divided into four groups: normal control (NC), diabetic control (DC), diabetic-HIIT1 with equal interval’s time (2 minutes) and diabetic-HIIT2 with low intensity interval’s time half the high intensity interval’s time (1 and 2 minutes, respectively). Pearson correlation was used to evaluate the relationship between glucose and IGF-1R factors. For normalcy of data, Shapiro–Wilk test was used and for homogeneity of variance, Levene's test was used. Significance level was  α = 0.05 in all stages. The results indicated that of IGF-1R gene the expression increased in both types of HIIT compared to the diabetic control group. Glucose levels also declined. However, no difference was noted between the effectiveness of both types of training. As a result, one can say that both types of HIIT are found to be effective in improving glucose and IGF-1R gene expression. However, no difference was observed in the IGF-1R gene expression between HIIT1 and HIIT2. Therefore, it is suggested that enough time be allotted for the sick and disabled people (diabetics) to take rest when performing HIIT so that they can practice for a longer period of time.