Abstract

Cancer is the third cause of death after coronary diseases and accidents. Breast cancer is a malignant proliferation of epithelial cells of the breast ducts or lobules. Breast cancer is one of the main problems of the health system for women in all countries, including our country. Annually more than 1.3 million people with breast cancer are recognized worldwide, with hormones playing an important role in the development of breast cancer. Investigating the factors and tumor markers are highly effective in diagnosis. Therefore, in this study, the effect and relationship between tumor markers and the neutrophil to lymphocyte ratio in patients were investigated for earlier diagnosis. The statistical sample consisted of all female patients with breast cancer aged 18-70 years who referred to Semnan hematologic clinic during 2009-2015 for the diagnosis and treatment. The number of these patients was 178. The initial CBC of these patients and the results of the hormonal and receptor analysis as well as the pathologic outcomes of the patients were investigated and analyzed by the Spss18.0 software after examining the patient records. The results showed that there was no significant relationship between the ratio of neutrophil to lymphocyte and ER receptor (p = 0.871), PR (p = 0.893), HER2 (p = 0.259). The overall results showed that with increasing the tumor progression and metastasis, the NLR increases. There is also no relationship between the ER / PR hormone receptors and the HER2/neu with the NLR.