Abstract

The present research work has been undertaken with both Mussaendaphilippica and Mussaendaincana for antioxidant screening and to investigate the anti-inflammatory activity. Anti-inflammatory activity was done by carrageenan induced Hind paw edema method using a plethysmometer. Diclofenac used as a standard drug and control receive saline. Antioxidant activity was evaluated by DPPH assay method. For both of these activity test groups received methanolic extract (100, 200 and 400 mg/kg). Phytochemical screening of extracts of Mussaendaphilippica and Mussaendaincanarevealed the presence of carbohydrates, Saponins, phytosterols, fix oil and fat,tannins, flavanoids and glycoside. In acute oral toxicity study, it was observed that there was no mortality at any doses up to 2 gm/kg. Both methanolic extract shows anti-inflammatory and antioxidant activity. The present studies support traditional use of Mussaendaphilippica and Mussaendaincanafor its anti-inflammatory activity.