Patel Rajesh M. and Patel Natvar J.

Abstract

Many coumarins and their derivatives exert anti-coagulant, anti-tumor, anti-viral, antiinflammatory and antioxidant effects, as well as anti-microbial and enzyme inhibition properties. The different substituents in the coumarin nucleus strongly influence the biological activity of the resulting derivatives. Although some coumarins have been already characterized to evoke a particular biological activity, the challenge would be the design and synthesis of new derivatives with high specific activity against different forms of free radicals and define their mechanism of action to achieve new therapeutic drugs against disorders results from oxidative damage. The present research work highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anti-oxidant agents. The major challenges about coumarins include the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of oxidative disorders. In present article, various coumarin compounds were evaluated for in vitro antioxidant activity by DPPH, Super oxide and nitric oxide free radical scavenging assay methods. From results of DPPH, super oxide and nitric oxide methods, it found that compound I and II displayed strong antioxidant (P < 0.001) activity compared to the ascorbic acid.