Samsuar Samsuar , Wasinton Simanjuntak , Hardoko Insan Qudus , Yandri Yandri , Dian Herasari , Sutopo Hadi

Abstract

In vitro antibacterial activity of some organotin(IV) chlorobenzoates including diphenyltin(IV) o-, m-, p-dichlorobenzoate (2, 3, 4) and triphenyltin(IV) o-, m-, p-chlorobenzoate (6, 7, 8) against Staphylococcus aureus and Escherichia coli was studied. The compounds were synthesized by the reaction of diphenyltin(IV) dihydroxide (1) and triphenyltin(IV) hydroxide (5) with o-, m-, p-chlorobenzoic acid in a maximum refluxed time of 4 h using methanol as the solvent of the reaction. The antibacterial activity tests were performed using the diffusion and dilution methods with chloramphenicol and methanol were used as a positive and a negative control, respectively. The antibacterial activity was determined by measuring the diameter of the inhibition zone in each test. The results showed that all compounds synthesized were active against S. aureus, where the largest inhibition zone diameter was observed to be > 16 mm for triphenyltin(IV) o-chlorobenzoate (6) with its smallest concentration of 300 ppm (5.935 x 10^-4 M), however, none of the organotin(IV) chlorobenzoates synthesized has activity against E. coli‎.

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