Pranati. T, Lakshmi Thangavelu, Anitha Roy

Abstract

Introduction: To assess the hepatoprotective property of organic green tea in Chang liver cell line. Green tea is found to have anti-inflammatory, anti-oxidative, anti-mutagenic and anti-carcinogenic properties and also helps in preventing cardiac disorders, gives protection against solar UV rays, maintains body weight and prevents Intestinal Dysbiosis and infection. Materials and methods: Green tea extract was evaluated for hepatoprotective property against CCl4 induced toxicity. This is done by MTT assay and by evaluating the ALT and AST levels in vitro study. Results: This study proves that green tea extract can be used as a potent hepatoprotective drug against CCl4 induced hepatotoxicity. Results of MTT assay show that the cell viability is >80% even at higher concentration of 120µg/ml of green tea and hence considered to be nontoxic. Also from the results of in vitro study, it has been proved that pre-treatment with green tea exact prevented Chang liver cells from CCl4 induced hepatotoxicity. This can be appreciated by the reduced levels of ALT and AST in green tea extract treated Chang cell lines in contrast with untreated Chang cell lines upon CCl4 induced toxicity. Conclusion: This study proves that green tea extract can be used as a potent hepatoprotective drug against CCl4 induced hepatotoxicity.