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Formulation Development of Suitable Osmotic Drug Delivery System for Highly Water Soluble Drug

Millin R Gohel , Adarsh Shah , Umesh M Upadhyay


An oral osmotic drug delivery system that can deliver ropinirole hydrochloride for extended period of time has been developed and characterized. Push Pull Osmotic Pump were developed in the work. Formulations were formulated using wet granulation technique. The tablets were coated with semipermeable coating polymer i.e. cellulose acetate. At the end tablets were drilled. When such systems come in contact with the medium, the PEO forms viscous gel and controls the drug release, whereas sodium chloride increases the drug release. In push pull system the push layer swells releasing the drug at a controlled rate. In advanced Parkinson’s disease the usual dose of ropinirole hydrochloride is 0.25mg- 5mg three to four times a day. Hence, an attempt was made to develop a once-a-day controlled release system. This may offer significant patient benefits by providing enhanced efficacy and reduced side effects and may also reduce the number of daily doses compared to conventional therapies. The developed push-pull osmotic system showed the desired once-a-day release kinetics. From the optimized batch the drug release was found to follow zero order kinetics with regression co-efficient of 0.9906. The optimized batch was found to be stable during the period of 3 months.

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