Abstract

The goal of the present investigation was to develop a topical gel of valdecoxib using two different gelling agent carbopol 934 and HPMC (K4M) in different concentrations, which assuages the gastrointestinal related toxicities associated with oral administration. They were evaluated for physicochemical properties such as homogeneity, grittiness, viscosity, pH, Spreadability, drug content and in vitro drug release. The results of in vitro drug release of formulated gel was evaluated using Franz diffusion cell containing cellophane membrane and the studies showed that as the concentration of gelling agent increases, drug release from gel decreases with reference to time. Thus, one can conclude that the drug absorption will be prolonged from site of application as long as it remains in higher concentration of gelling agent.