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Formulation and Evaluation of Transdermal film of Promethazine Hydrochloride

Umesh. D. Shivhare , Pravin. B. Suruse Taher S. Dahodwala Azaruddin Sheikh


In present study Promethazine hydrochloride transdermal films were prepared by mercury substrate method using polymer Eudragit RS 100 and Eudragit RL 100. Dimethyl sulphoxide and Dibutyl phthalate were used as a skin permeation enhancer and a plasticizer, respectively. The prepared transdermal films were evaluated for thickness, folding endurance, weight variation, flatness, moisture absorption, moisture loss, moisture content, water vapor transmission, drug contain uniformity and in vitro permeation study. Drug polymer interactions were determined by FTIR and standard calibration curve of Promethazine hydrochloride was determined by using UV spectroscopy. In vitro drug release study was performed by using Franz-diffusion cell. The transdermal films prepared by using Eudragit RS 100 and Eudragit RL 100 showed good physical properties. The formulation batch (F5) containing Eudragit RL 100: Eudragit RS 100 (5:1) showed maximum drug release (96.15%) and showed fickian diffusion.

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