Mohit Tomar, Neha Tomar, Neha Gulati, Upendra Nagaich, Amit Chaudhary, Bhavya Rastogi

Abstract

The aim of the present work was to fabricate and characterize caffeine loaded floating tablets loaded as sustained release dosage forms. Several formulations were prepared by varying the concentrations of sodium bicarbonate and citric acid. Floating tablets were prepared using HPMC as a binder and sodium bicarbonate as gas generating agents. The prepared floating tablets were evaluated for tablet properties such as hardness, thickness, friability, weight variation and floating property. In vitro dissolution was conceded out for about 16 hrs in 0.1N HCl at 37±0.5 °C using USP paddle type dissolution apparatus. It was noted that, all the prepared formulations had desired floating lag time and constantly floated on dissolution medium. The drug release from floating tablets was found that the varying concentration of the polymer affected the drug release. In the present surveillance that floating drug delivery system can be prepared and evaluated.