Alireza Bakhshipour, Hamed Taheri, Fatemeh Heidari, Hosnieh Khoobkhahi

Abstract

Introduction: One of the most common gastric complaints associated with complications is dyspepsia, and therefore, early detection of high-risk individuals by minimally invasive procedures is necessary because it is related with some gastric malignancies. Therefore, we seek to determine the association between serum levels of pepsinogen, gastrin-17 and anti-Helicobacter with pathological alterations in the stomach in patients with dyspepsia over 25 years of age in this investigation. Methods: After the patients were contented and demographic information were recorded, serum levels of pepsinogen, gastrin 17, and anti-helicobacter and gastric pathology, this cross-sectional study was carried-out on a statistical population consisting of 169 patients with dyspepsia. To compare the data, Chi-Square and Mann-Whitney U tests were used. Results: The results of the present study showed that chronic gastritis, helicobacter pylori bacilli, erosive gastritis, atrophic gastritis, dysplasia and metaplasia were seen in 67.5, 72.8, 41.4, 38.5, 6.5 and 3 percent of dyspeptic patients, respectively. It was also found that the levels of four biomarkers such as pepsinogen I and II, gastrin-17 and anti-Helicobacter increased in chronic gastritis, helicobacter pylori bacilli, and erosive gastritis. However, serum pepsinogen I levels alleviated in dysplasia, metaplasia, and atrophic gastritis, while serum gastrin-17 levels and anti-Helicobacter increased in these diseases. Conclusion: The reason for preventive measures in high-risk individuals and screening based on serum levels, is the high frequency of pathological findings in dyspeptic patients and the relationship of these findings with serum levels of biomarkers that are studied.