Abstract

Introduction: Prescription of glucose insulin potassium (GlK) affects the heart function with different mechanisms. GIK leads to metabolic support of myocardial muscle, reduced ischemia, and increased heart function reconstruction. Since lactate is a marker susceptible for heart function and saturation of central venous oxygen (SCVo2) is also useful in evaluating heart muscle perfusion, this study was conducted to evaluate the effect of injection of GIK solution on heart function using the indicators of serum lactate and saturation of central venous oxygen. Methodology: This double-blind clinical trial was performed on 74 patients aged 30-85 years undergoing coronary artery bypass grafting surgery. Patients were divided into two groups of GIK and control, and atrial fibrillation variables, the need to use inotropic, discharge time, serum lactate and SCVO2 levels 24 and 48 hours after surgery were compared in two groups using independent t-test, paired t-test, chi-square, and ANOVA. Results: the use of inotropic (P <0/01), incidence of AF (P = 0.003), discharge time of patients (P = 0.005) and death rate (P = 0.5) were higher in GIK group than those in the control group. In addition, serum lactate was higher in the control group (P <0.001) and CVO2 was higher in the GIK group 24 hours after surgery and 48 hours after surgery (P <0.001).