Abstract

background: Thalassemia is an autosomal genetic condition in which hemoglobin loses its natural structure and results in ineffective hemoglobin in the body. Blood transfusion to these patients is one of the most important causes of iron deposition in the body's organs (including the heart), which causes organ dysfunction. One of the best ways for patients to monitor their iron deposition is to use magnetic resonance imaging (MRI) and measure T2 * in their liver and heart. In this study, the relationship between left ventricular function of patients with thalassemia major Beta and iron deposition in myocardial and hepatic tissues using transverse relaxation T2 * time calculated by MRI was investigated. Methods: Twenty-two patients were randomly selected from Shaheed rajaei Cardiovascular and medical research center. Cardiovascular MRI was performed with the relevant protocols to measure the parameters. R2*, T2*, and cardiac function were extracted and then Student t-test was used and finally, the T2* To each of the desired cardiac performance indicators, the correlation and threshold of left ventricular changes in patients with iron deposition were determined. Results: In this study, it was found that there is a significant linear relationship between decrease in left ventricular ejection fraction with T2* values in patients and 55% of left ventricular ejection fraction decrease is due to iron deposition (P <0.05). Conclusion: According to the results, proper follow up of patients with Beta thalassemia major, using MRI, at the right time we can be aware of the of iron deposition that could increase the risk of heart failure and arrhythmias and we can perform appropriate treatment to decrease complications.