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Estimation of the healing effects of the topical use of MEBO and hyaluronic acid gel in the burned rats


Safa Mustafa Najim , Ammar A. Fadhil , Muhammed Naeem Abdullah , Luma Eassa Hammodi

Abstract

Exposing the dorsal superficial skin of rats to partial-depth burn leads to bacterial and microbes Invasion. Topical treatment is required in most superficial burn cases Moist exposed burn ointment (MEBO) protects wounds from infection and enhances healing without any harmful effects of purified chemicals is caused. The topical using of HA gel in rat models with full and partial thickness surgical wounds shows enhancement in wound repair. In this study, we compared the healing efficacy of topical use of hyaluronic acid gel products with MEBO as standard management in rats that were exposed to a partial-thickness burn. The experiment included twenty-four (24) adult albino rats of male sex with weight (150-220 gm) of 3 months’ age divided into four groups. Partial-thickness burn wounds are applied on their shaved dorsal skin by a hot metal plate for 4 seconds. Group I: control group received topically normal saline as a vehicle placebo, group II: are treated topically with MEBO, Groups III & IV: are treated topically with hyaluronic acid gel (Afta Med and Gum Afta Clear) respectively twice daily for 14 days. The burn wound area was daily examined and measuring the diameter of the lesion area was until day 14 and photographs of the lesion area and wound repairs were taken at different time intervals (0,3,5,7, 10, and 14). % of wound contraction also detected. The rats were sacrificed on days 11 and 14, then elevates 5 mm of diameter full-thickness flap of healed and unhealed wound areas. Wound healing occurs faster when using HA gel products topically for treatment of the induced partial-thickness burn when compared with using MEBO and control group which was supported with histological examination and statistical analysis.


How to cite this article:
Vancouver
Najim SM, Fadhil AA, Abdullah MN, Hammodi LE. Estimation of the healing effects of the topical use of MEBO and hyaluronic acid gel in the burned rats. J Adv Pharm Educ Res. 2022;12(2):91-7. https://doi.org/10.51847/JO4odidwgl
APA
Najim, S. M., Fadhil, A. A., Abdullah, M. N., & Hammodi, L. E. (2022). Estimation of the healing effects of the topical use of MEBO and hyaluronic acid gel in the burned rats. Journal Of Advanced Pharmacy Education And Research, 12(2),91-97. https://doi.org/10.51847/JO4odidwgl
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