Samar Z. Alshawwa

Abstract

Background: Ciprofloxacin hydrochloride is a common antibiotic used for treating bacterial infections, and enhancing its antibacterial activity is considered a crucial concern of scientific researchers. Objectives:  The objective of this work aim to show the enhancement of the antibacterial activity of ciprofloxacin ocular inserts against P. aeruginosa and S. aureus. Method: The enhancement of antibacterial activity of ciprofloxacin ocular inserts against P. aeruginosa and S. aureus  was evaluated using microbiological susceptibility tests. The inserts composed of two types of spray-dried matrices, SD₁ and SD₂. Results: Promising results were obtained and the two formulae were found to be effective against S. aureus and P. aeruginosa, also the results indicated clear zones of inhibition every day up to seven days. Conclusion: It was concluded that ciprofloxacin hydrochloride is a good antibacterial agent.