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Nahed Sail Alharthi

Abstract

Endocannabinoids (ECs) are characterized as the endogenous ligands of cannabinoid recep-tors (CRs). The research in the field of the endocannabinoid system (ECS) has forecasted a promising role that ECS could play in developing an understanding and management of nu-merous physiological disorders and several diseases. There is a range of analytical techniques that have proved to be fruitful in diagnosing and learning the metabolic and pathological role of these receptors/mediators through various biological indices. Since drug rehab is much faster and less taxing than introducing a new one into the clinic, we may anticipate that the prevailing pharmacology science and data analysis on the ECS shall provide for its effective translation into medical sciences. CB1 and CB2 (G protein-coupled receptors, GPCR) form protein complexes with other GPCRs and non-GPCRs and play a distinctive role in cell sig-naling. This induced inflection of ECS may be modulated for the better of the health care system. This review aims to explore the potential of ECS and new EC-like molecules in clini-cal physiology, pathology, and overall metabolism. The complex ECS that is involved in al-most all aspects of mammalian physiology, pathology, and the range of these maneuvers is debated in this review, as well as they could also be used as drug candidates in the innovation of cannabinoid-based pharmaceutical drugs for a range of diseases‎.

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