× Copyright Disclaimer Privacy Policy Author Guidelines Current Issue Archive Publishing Ethics Join As Reviewer Advertise Submit Article Abstracting And Indexing Editorial Board Contact Editor-in-Chief Scope of the Journal About the Journal


JAPER is indexed in SCOPUS

Views: 60 Downloads: 21

Effects of the Roux-en-Y gastric bypass on DM and renal function in obese patients


Ahmad Nezhadrahim, Matin Moallem Shahri, Nosrati Negarin Akbari

Abstract

Obesity is one of the major issues in the health of the population worldwide. Roux-en-Y gastric bypass (RYGB) is considered a safe and effective treatment in obese patients. In addition RYGB has shown therapeutic potential in type 2 diabetic patients. This study represents a 6 months follow-up on 63 obese patients with BMI≥40 Kg/m3, suffering from both DM2 and CKD, who underwent LRYGB. From 900 obese patients referred to Imam Reza, Sina, and Bentolhoda Hospitals of Mashhad University of Medical Sciences in 2019, 63 were selected for LRYGB. The patient’s diabetic status evaluation 180 days post-surgery revealed that, from 30 patients who used insulin injection before RYGB, 20 (66.6%) achieved full remission, 9 (30%) showed improvement and 1 (3.3%) showed no change in their diabetic state. From 22 patients who received concomitant oral and insulin therapeutic regimens, 11 (50%) achieved full remission, while 9 (40.9%) showed improvement and 2 (9.1%) showed no change in their status. All the patients who received oral medications for DM treatment achieved full remission post-surgery. Duration of obesity was not correlated with either ∆HbA1c or ∆GFR, however, duration of T2DM showed a significant correlation with ∆HbA1c (P-value≤0.05). No correlation between T2DM duration and ∆GFR was observed. In conclusion, RYGB is considered a promising approach for T2DM treatment and CKD in obese patients with BMI≥40 Kg/m3, and its therapeutic effects are due to metabolic alterations rather than weight reduction alone. However, technical considerations in AL and BL lengths for achieving optimal results are under debate.


How to cite this article:
Vancouver
Nezhadrahim A, Shahri MM, Akbari NN. Effects of the Roux-en-Y gastric bypass on DM and renal function in obese patients. J Adv Pharm Educ Res. 2023;13(1):1-5. https://doi.org/10.51847/c60nSRP6Q7
APA
Nezhadrahim, A., Shahri, M. M., & Akbari, N. N. (2023). Effects of the Roux-en-Y gastric bypass on DM and renal function in obese patients. Journal of Advanced Pharmacy Education and Research, 13(1), 1-5. https://doi.org/10.51847/c60nSRP6Q7
Citation Formats:


Contact SPER Publications


SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India