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Effect of variables on Naproxen Agglomerates Engineered by Melt Sonocrystallization

Ravindra Kamble , Priyanka Nangare , Lalit Garge


The study deals with melt sono crystallization (MSC) technique for the preparation of agglomerates of naproxen. Purpose is to improve the solubility and compressional properties of naproxen. In the present study naproxen agglomerates prepared by MSC and melt solidification technique (MST) and the effect of variables like time of sonic energy, amplitude and temperature of the deionized water on agglomerates were compared. The technique involves application of ultrasonic energy to the soft viscous or molten mass, dispersed in suitable dispersion media maintained at suitable temperature, with or without agitation. The technique developed for naproxen using 33 factorial designs. Obtained agglomerates were evaluated and compared on the basis of true solubility, scanning electron microscopy (SEM), Fourier transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), heckle plot, particle size distribution (PSD), drug release, angle of repose, bulk and tap density. The improved compressional and solubility properties were confirmed by application of MSC. As the time of sonication and temperature was increased, the percent yield, dissolution rate and true solubility were found to be decreased. Intermediate level of time of sonication, low level of amplitude and temperature gives maximum release of drug.

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