Hany Mohamed Ahmed Wahba, Maha Hanafy Mahmoud, Hanaa Farouk El-Mehiry

Abstract

Background and objectives: Cisplatin which is used widely for cancer patients as an effective chemotherapeutic drug was reported to exert many adverse effects on the body. This study aims to investigate the effect of quinoa seeds against cisplatin toxicity in female rats. Materials and methods: Thirty six female Wistar rats were used. Thirty of them were divided into five groups each of six rats and injected daily for 8 weeks intraperitoneally with cisplatin dose of 12 mg/kg b. wt./rat, while the remaining group was considered as the negative control and injected intraperitoneally by saline for the same period. The negative control group and the positive control group (injected with cisplatin) were fed on basal diet, the third, fourth, fifth and sixth groups were fed on basal diet + 10% or 20% or 30% or 40% quinoa seed powder, respectively. Results: The results revealed that rats consumed quinoa seed powder at different levels showed significant increase in concentration of serum testosterone, estrogen, follicle stimulating hormone (FSH) and luteinizing hormone (LH), compared to the positive control group. Also, administration of quinoa seed powder at different levels improved kidney function, liver enzymes, lipid profile and antioxidant parameters in female rats. Conclusion: The quinoa seed powder is a potent polyphenol, mineral and vitamin rich source with great anti-inflammatory and antioxidant power which can be used to prepare a functional food that can counteract the symptoms of cisplatin toxicity and prevent its complications.