Abstract

Parkinson's disease is caused by the loss of dopamine-secreting cells. The neuropathological characteristic of this disease is the destruction of dopaminergic neurons in the midbrain black substance. The aim of this study was to investigate the effect of eight weeks of aerobic training on some of the neurotrophic and growth factors of hippocampal tissue of mice with Parkinson's disease induced by 6-hydroxydopamine. Methodology: we purchased thirty male Wistar rats from the Pasteur Institute of Tehran and transferred to the Research Center. Animals will be randomly divided into two groups of Parkinson's and Exercise after entering the research environment and two weeks of acquaintance with the new environment and mode of activity. Results: The results of this research showed that eight weeks of aerobic training significantly increased BDNF levels (P = 0.0000) and significantly increased GH (P = 0.0000) in Parkinson's rat. Discussion: The results of this research showed that eight weeks of aerobic training increased the levels of neurotrophic factors and growth hormone in the brains of Parkinson's rats‎.