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Different approaches toward the enhancement of Drug Solubility: A Review

Amruta B. Varandal , D. D. Magar , R.B. Saudagar


As we know that for achieving therapeutic effect in human body, drug should be bioavailable and hence it depends on solubility of drug. Recently 40% of the drugs are poorly water soluble which produce side effects such as gastric irritation, peptic ulceration etc. whereas only 8% of new drug candidates have both high solubility and permeability. For BCS class II drugs, enhancement of solubility is important parameter before formulation of dosage form. The aim of this review is to improve the solubilization and bioaviailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques and included BCS classification, carriers for solubility enhancement and different techniques for solubility enhancement.

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