Inna Baranova, Sergei Zaika, Yuliia Bezpala, Olena Roik, Svitlana Zaporozhska, Liubov Shostak

Abstract

Introduction: Seborrheic dermatitis (SD) is a chronic inflammatory recurrent dermatosis characterized by erythematous-squamous rashes in areas with hypertrophied and hyperactive sebaceous glands. The key factor in the pathogenesis is changes in the functional activity of the sebaceous glands by various exogenous and endogenous factors, accompanied by the activation of Malassezia genus. Topical glucocorticosteroids, and antimicrobial and antifungal agents are used to treat the disease. However, most of them have short-term effects, so finding new treatment approaches is necessary. Materials and Methods: Samples with active pharmaceutical ingredients and surface-active agents were provided. The anionic (disodium Laureth sulphosuccinate, sodium Laureth sulfate, sodium myreth sulfate, sodium lauroyl sarcosinate, magnesium Laureth sulfate), amphoteric (disodium cocoamphodiacetate, Cocamidopropyl betaine), and nonionic (ethoxylated rape oil amide, cocamide DEA, PEG–7 glyceryl cocoate, and PEG–200 glyceryl palmitate) surfactants were selected. The foaming ability of samples was determined by the modified method of Ross-Miles. The pH of the test samples was determined by potentiometry. The quality of the bases prepared was assessed according to appearance, organoleptic indicators (color, odor), рН, and foaming ability. Results and Discussion: This study devoted to the rational combination of anionic, amphoteric, and nonionic surfactants and studies of their foaming ability for the development of stable shampoo to treat seborrheic dermatitis. Conclusion: All foaming bases with anionic surfactants, namely, disodium laureth sulphosuccinate, sodium Laureth sulfate, sodium myreth sulfate, and sodium and magnesium Laureth sulfate had satisfactory physicochemical indicators. The obtained data will be considered at the next stage of our research, when it is planned to introduce into the elaborated foaming bases a complex of active pharmaceutical ingredients, the concentration of which is substantiated based on biological and microbiological researches. There is also planned research regarding the study of foam structure by microphotography method‎.