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Development and Validation of UV Spectrophotometric method for the Simultaneous estimation of Ciprofloxacin Hydrochloride and Ornidazole in Combined Pharmaceutical Dosage Form

J. Ramya Krishna , B. Naga Sandhya , Sanayaima Huidrom , V. V. L. N Prasad


A simple, precise, accurate and economical UV Spectrophotometric method has been developed and validated for the simultaneous estimation of Ciprofloxacin and Ornidazole in combined pharmaceutical dosage form using simultaneous equation method. Ciprofloxacin hydrochloride has absorbance maxima at 270 nm and Ornidazole has absorbance maxima at 319 nm in distilled water. The drugs obeyed beer’s law in the concentration range of 2-12 μg/ml for Ciprofloxacin and 6-16 μg/ml for Ornidazole. The correlation coefficient of Ciprofloxacin HCl and Ornidazole was found to be 0.999 and 0.997 respectively. The method was statistically validated as per the ICH guidelines. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The developed method was simple, precise, accurate, reproducible and economical which can be efficiently and easily applied to pharmaceutical dosage form.

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