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Development and validation of new ICP-OES Analytical Technique to quantify the contents of Copper, Magnesium & Zinc in “Escitalopram Oxalate”


Mamatha Veeramachaneni , Kumar Raja Jayavarapu

Abstract

An accurate, precise , reproducible and eco friendly Inductively Coupled Plasma Optical Emission Spectroscopic (ICP – OES) method was developed and validated for the estimation of Copper, Magnesium and Zinc in Escitalopram Oxalate drug. The method is selective and is capable of detecting copper, magnesium and zinc in the presence of other elements. The method has been validated using RF power of 1150 watts, plasma flow of 15L/min, and Nebuliser flow of 0.6 L/min and plasma view at axial mode for all the elements. The wavelength was monitored for copper; magnesium and zinc are at 324.754 nm, 285.213 nm and 213.856 nm respectively. The method has been validated in terms of specificity, precision, linearity, accuracy, limit of quantification. The objective of the study is to provide an alternate economical method to estimate the contents of elements in escitalopram oxalate.




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