Abstract

Background: Thalassemia is an autosomal genetic disease in which hemoglobin has lost its natural structure and an ineffective hemoglobin in the body is produced. Blood transfusion to these patients is one of the most important causes of iron deposition in the organs of the body, including the heart. Sediment causes organ dysfunction. One of the best ways of monitoring these patients to examine sediment, using MRI and measurement of T2 * index in their heart and liver. In this study, the relationship between heart T2 * and serum ferritin levels in patients with thalassemia major has been evaluted. Materials and Methods: Seventeen patients were assigned randomly among the patients referring to the Shahid Rajaee Cardiology Center.  Cardiovascular MRI was performed with the relevant protocols for measuring T2 *, and the values of R2 * and T2 * were extracted and then, using Student-t correlation between values with experimental results of serum ferritin was compared and finally the Pearson coefficient was calculated between the results of the above study and the severity of the relationship Between values set. Results: In this study, the correlation between the amount of ferritin and T2 * heart was computed to be 0.36, indicating that high ferritin concentration only accounts for 36% of iron deposition detemination role in myocardium and there are other factors contribute to the deposition of 64% of the remainder.