Abstract

Introduction: Fractures of the extremity are common and presents with moderate or severe pain in 80% of patients. It seams route of administration may modify the pain relief and adverse complication of medications. This double blind, randomized, clinical trial was conducted to evaluate the safety and efficacy of morphine suppositories versus intravenous morphine for acute pain control in patients with extremity fractures for the first time. Materials and Methods: 230 patients with extremity fracture were randomly divided into two groups, 5 ml of distilled water with morphine suppositories and the 115 other patients, 5 ml intravenous morphine suppositories given placebo. The patients of pain at 0, 15 and 30 minutes and 1, 3, 6, 12, 18 and 24 hours and analgesic drugs and the need to repeat medical complications were studied. Results: Patient satisfaction in both groups received morphine analgesia of intravenous and rectal suppositories Please not significantly different (p=0.85). Nausea and vomiting, and loss of consciousness in the group receiving intravenous morphine was significantly higher (p <0.05). Conclusion: With regard to the application of the rectal and intravenous administration of morphine equivalent analgesia may be appropriate in patients with rectal as a method according to this method more secure and more convenient administration compared with intravenous administration.